The accuracy of pipetting not only requires the matching of the tip and the pipette, but also a tip suitable for the characteristics of the liquid. We often find a phenomenon in our operations. When using a standard tip to pipette liquids with low surface tension (such as liquids containing detergents), it is easy to leave a film on the inner surface of the tip. The kit samples used in many DNA and protein analysis methods usually contain detergents. Therefore, in experiments of this type of application, more liquid residues are common. The residual liquid will cause inconsistent pipetting results, and also loss of some expensive samples. The development of low retention tips is to improve the common problem of liquid residue.